Asymptotic properties of covariate-adaptive randomization
نویسندگان
چکیده
منابع مشابه
Asymptotic Properties of Covariate - Adjusted Adaptive Designs
Owing to the benefits that higher proportions of patients are likely to receive the better treatment, response-adaptive designs are considered to be valuable statistical tools in clinical studies. Nevertheless, there is a lack of a comprehensive study of adaptive designs with the inclusion of covariates, regardless of their importance in clinical experiments. The major reason is that covariatea...
متن کاملAsymptotic Properties of Covariate - Adjusted Response - Adaptive Designs
Response-adaptive designs have been extensively studied and used in clinical trials. However, there is a lack of a comprehensive study of responseadaptive designs that include covariates, despite their importance in clinical trials. Because the allocation scheme and the estimation of parameters are affected by both the responses and the covariates, covariate-adjusted responseadaptive (CARA) des...
متن کاملUsing Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization.
We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating the null distribution of a general test statistic by repeating the adaptive randomized treatment as...
متن کاملAsymptotic properties of the sample mean in adaptive sequential sampling with multiple selection criteria
We extend the method of adaptive two-stage sequential sampling toinclude designs where there is more than one criteria is used indeciding on the allocation of additional sampling effort. Thesecriteria, or conditions, can be a measure of the targetpopulation, or a measure of some related population. We developMurthy estimator for the design that is unbiased estimators fort...
متن کاملCovariate-based constrained randomization of group-randomized trials.
Group-randomized study designs are useful when individually randomized designs are either not possible, or will not be able to estimate the parameters of interest. Blocked and/or stratified (for example, pair-matched) designs have been used, and their properties statistically evaluated by many researchers. Group-randomized trials often have small numbers of experimental units, and strong, geogr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Annals of Statistics
سال: 2012
ISSN: 0090-5364
DOI: 10.1214/12-aos983